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Louisville
21C Museum Hotel Louisville
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From209US$ /night
Check-in
08Feb2026Select date
Check-out
09Feb2026Select date
Rooms and Guests2 Guests, 1 Room
Key details

Hotel Overview

700 West Main Street, Louisville, Kentucky, United States, 40202
-
Steps from Waterfront Park
Great
8.7
9.3
/10
4.6
4.5
/5
Loved by 21C Museum Hotel Louisville guests
  • Super clean rooms
  • Helpful staff
  • Innovative artwork
  • Plush beds
  • Really good service
"Art work throughout the hotel and galleries is fascinating."
Alice from United States
read full review
"Inside we were free to wander through the multi level museum and enjoy the contemporary artwork at our own pace."
Kleime from United States
read full review
"Unique property with two-floor onsite art gallery."
Eric from United States
read full review

21C Museum Hotel Louisville, a 5-star boutique hotel, offers a unique combination of contemporary art and luxury accommodations. It features an award-winning restaurant, Proof on Main, and over 9000 square feet of exhibition space.

Rooms & Amenities

Rooms at 21C Museum Hotel Louisville feature modern design elements, including premium Bryte Restorative Sleep Beds. Certain accommodations offer city views, while select rooms include multifunctional furniture designed by local artists.

Dining & Nearby Options

Dining at 21C Museum Hotel is highlighted by Proof on Main, renowned for its southern and Appalachian-inspired cuisine. Guests can enjoy a curated cocktail menu featuring local distillers.

Leisure & Services

Leisure opportunities at 21C include access to curated exhibitions and a nearby ZeroBus for convenient transport to local attractions. The hotel also hosts unique events, such as the Fork & Bottle dinner series featuring regional spirits.

Location & Transportation

21C Museum Hotel features dedicated event spaces accommodating up to 60 guests and is situated within a half mile of notable sites like the Kentucky Museum of Art & Craft and Louisville Slugger Museum. Public bus services are accessible within walking distance.

Must-do experiences

  • Visit the Muhammad Ali Center for inspiration and local history.
  • Savor a Hot Brown at the Brown Hotel, a true Louisville classic.
  • Stroll through the Big Four Bridge for stunning river views.
  • Explore the quirky shops at the historic Frankfort Avenue.
  • Check out the local art at the Zephyr Gallery in NuLu.
View all

Pick the Room That Suits Your Travel Needs

Rooms for singles, families, or groups—many with breakfast, free cancellation, and exclusive airport packages
Room Balcony
Room Balcony
2 persons
315 sq. feet 
1 King-size bed
Shower
Coffee machine
room details
Deluxe King Room
Deluxe King Room
2 persons
335 sq. feet 
1 King-size bed
Shower
Coffee machine
room details
Corner Suite
Corner Suite
2 persons
660 sq. feet 
1 King-size bed
Shower
Coffee machine
room details
Deluxe King Suite
Deluxe King Suite
2 persons
500 sq. feet 
1 King-size bed
Shower
Coffee machine
room details
Click button to see more rooms
Show all rooms
Show all roomsLess

View Room Rates & Availability by Date

Check rooms and compare prices for your travel dates today

Facilities

Comfortable Rooms and Convenient Services to Enhance Your Layover

General

  • No smoking on site
  • Free Wi-Fi
  • Car park
  • Safe deposit box
  • 24-hour reception
  • Pets allowed
  • Rooms/ Facilities for disabled
  • Wheelchair access
  • Security
  • Luggage storage
  • Locker room
  • Allergy-free rooms
  • Lift
  • ATM/Cash machine
  • Smoke detectors
  • Electric vehicle charging station
  • Fire extinguishers

Sports & Fitness

  • Fitness centre
  • Yoga class

Guest Parking

  • Cookware/ Kitchen utensils

Services

  • Valet parking
  • Room service
  • Housekeeping
  • Laundry
  • Dry cleaning
  • Welcome drink

Dining

  • Restaurant
  • Bar/ Lounge area
  • Outdoor dining area

Business

  • Business centre
  • Meeting/ Banquet facilities
  • Fax/Photocopying

Children

  • Cots

Spa & Leisure

  • Spa & wellness centre
  • Sauna
  • Turkish bath
  • Steam room
  • Full body massage

Room features

  • Air conditioning
  • Heating
  • Mini-bar
  • Soundproofed rooms
  • Patio
  • Tea and coffee facilities
  • Ironing facilities

Bathroom

  • Free toiletries

Self-catering

  • Cookware/ Kitchen utensils

Media

  • Flat-screen TV

Room decor

  • Carpeted floor
Show more

Dining Onsite

Experience a delightful fusion of modern American flavors at Proof on Main, nestled within the 21C Museum Hotel Louisville. With a contemporary setting infused with art and elegance, this dining venue promises a memorable culinary adventure, featuring events that celebrate regional distillers and renowned spirits.
21C Museum Hotel Louisville Restaurant photo
21C Museum Hotel Louisville Restaurant photo
21C Museum Hotel Louisville Restaurant photo

Proof on Main

American
Ambiance
Modern and artistic, with an environment that melds a contemporary restaurant feel with the vibrant artistry of the hotel.
Key Offerings
Signature dishes include locally sourced fare and craft cocktails. Look out for extraordinary events like the Fork & Bottle dinner series, showcasing guest distillers from the region, and the exclusive annual Hog & Barrel dinner featuring Pappy Van Winkle.
Reservation
Recommended.
Hours vary.

Location & Directions

700 West Main Street, Louisville, Kentucky, United States, 40202
Map view
700 West Main Street, Louisville, Kentucky, United States, 40202
City landmarks
Square
Fourth Street Live
2700 ft
Stadium
Louisville Slugger Field
1.0 mi
Event hall
Kentucky International Convention Center
3000 ft
Landmark
KFC Yum Center
2300 ft
Park
Waterfront Park
4400 ft
Church
Cathedral of the Assumption
2100 ft
Landmark
Freedom Hall
3700 ft
Museum
Thomas Edison House
1.3 mi
Landmark
Angel's Envy Distillery
5200 ft
Landmark
Jim Beam Urban Stillhouse
2900 ft
Bridge
Big Four Bridge
1.4 mi
Library
Louisville Free Public Library
4800 ft
Bridge
The Big Four Bridge
1.4 mi
Landmark
Old Forester Distilling
4000 ft
Landmark
West Main Historic District
1.4 mi
Museum
African American Heritage House Museum
1.3 mi
Park
Falls of the Ohio State Park
2.5 mi
Nearby
Museum
Louisville Slugger Museum & Bat Factory
600 ft
Museum
Muhammad Ali Center
1000 ft
Museum
Kentucky Science Center
500 ft
Museum
The Frazier History Museum
900 ft
Museum
Kentucky Museum of Art and Craft
300 ft
528 W Main St
Evan Williams Bourbon Experience
700 ft
Gallery
Flame Run Glass Studio and Gallery
1000 ft
500 W Main St
The Belvedere
900 ft
Night club
Jimmy Can't Dance
300 ft
801 W Main St
Michter's Fort Nelson Distillery
500 ft
Library
Sons of the American Revolution Genealogical Research Library
700 ft
120 N 10th St
Kentucky Peerless Distilling Co
1600 ft
401 W River Rd
Belle of Louisville Riverboats
2000 ft
Restaurants
Proof On Main
100 ft
702 West Main Street
Mussel & Burger Bar Downtown
200 ft
113 S 7th St Located in Louisville's Central Business District
Bristol Bar & Grille
400 ft
614 W Main St
Atlantic No. 5
600 ft
605 W Main St Located in Louisville's Central Business District.
Los Aztecas Mexican Restaurant
600 ft
445 E Market St
Vincenzo's Italian Restaurant
1500 ft
150 S 5th St
Jockey Silks Bourbon Bar
1600 ft
140 N 4th St 2nd Floor - West Tower
Dish on Market
1600 ft
434 W Market St
Quiznos
1800 ft
223 S 5th St
Swizzle Dinner & Drinks
1800 ft
140 N Fourth St 25th Floor
Cafe Magnolia
2000 ft
140 N 4th St Galt House Hotel
Explore Louisville
Experience Louisville
Top Attractions
Activities
Dining
Entertainment
Kentucky Science Center
Kentucky Science Center
2 minutes walking
Interactive exhibits and IMAX films. A hands-on learning experience perfect for families.
Louisville Slugger Museum & Bat Factory
Louisville Slugger Museum & Bat Factory
3 minutes walking
Home of the iconic baseball bat. Guided tours showcase the bat-making process and memorabilia.
Muhammad Ali Center
Muhammad Ali Center
4 minutes walking
Cultural center dedicated to the life and legacy of Muhammad Ali. Inspiring exhibits on personal growth.
The Frazier History Museum
The Frazier History Museum
4 minutes walking
Focuses on Kentucky's history. Offers engaging exhibits and local artifacts reflecting diverse heritage.
Waterfront Park
Waterfront Park
17 minutes walking
Scenic park ideal for jogging or picnicking along the river. Offers playgrounds and beautiful views.
Angel's Envy Distillery
Angel's Envy Distillery
19 minutes walking
Offers distillery tours with tastings of their unique bourbon. Reservations recommended, suitable for enthusiasts.
Yoga by the Water
15 minutes walking
Outdoor yoga classes held in Waterfront Park. Great for relaxation and refreshing your spirit.
Big Four Bridge
Big Four Bridge
25 minutes walking
Historic bridge connecting Kentucky and Indiana, great for biking or a family stroll, with stunning views.
Proof On Main
Proof On Main
1 minute walking
Artful dining experience with a focus on local ingredients. Signature dishes include bison short ribs.
Mussel & Burger Bar Downtown
Mussel & Burger Bar Downtown
1 minute walking
Casual atmosphere specializing in gourmet burgers and fresh mussels. Vegetarian options available.
Bristol Bar & Grille
Bristol Bar & Grille
2 minutes walking
Inviting bar atmosphere with a diverse menu. Known for their fresh seafood and farm-to-table ingredients.
Los Aztecas Mexican Restaurant
Los Aztecas Mexican Restaurant
3 minutes walking
Vibrant spot for authentic Mexican dishes. Popular for tacos and enchiladas, catering to various dietary needs.
KFC Yum Center
KFC Yum Center
9 minutes walking
State-of-the-art arena hosting concerts and sporting events. Family-friendly shows frequently scheduled.
Fourth Street Live!
10 minutes walking
Lively entertainment district with bars, restaurants, and clubs. Nightly live music adds to the vibrant atmosphere.
Louisville Slugger Field
Louisville Slugger Field
20 minutes walking
Home of the Louisville Bats, offers a fun family outing. Enjoy baseball games in a picturesque setting.
The Comedy Caravan
10 minutes driving
Local comedy club featuring stand-up acts. Offers a casual setting for an entertaining night out.
How to Navigate the City
City Centre
Louisville23 min  ·  1.2 mi
Airports
Louisville International Airport (SDF)18 min  ·  7.4 mi
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Property information and rules
Check-in
from 16:00-23:59
Check-out
until 11 am
Guest Parking
No parking available.
Internet
is available in for free.
Children & extra beds
Maximum capacity of extra beds in a room is 1. 
Pets
Pets are allowed on request.
Year renovated:
2006
Number of floors:
4
Number of rooms:
96
Former name
21c Museum Hotel
Questions of the users
About 21C Museum Hotel Louisville
Do any of the rooms at 21C Museum Hotel Louisville have a balcony for enjoying the view?
14 March 2024
The Luxury King rooms do not feature balconies, but there are two balcony suites and one penthouse with an expansive 185.8 sq. m terrace available.
What are the parking options available for guests at the hotel?
22 April 2024
Valet parking is offered at a rate of $32 per night, which allows unlimited access to your vehicle. Alternatively, self-parking is available on surrounding streets or in a nearby parking garage.
Could you please provide details on the pet policy and fees for small dogs?
10 May 2024
A $75 pet fee per room is applicable for guests bringing small dogs weighing under 9 kg.
Is there an option to block rooms for wedding parties or special occasions?
18 June 2024
Yes, inquiries regarding room blocks for wedding parties can be directed to the hotel's sales team for assistance.
Do the balcony rooms offer any kind of view, specifically of the river?
26 July 2024
The balcony rooms overlook 7th Street, while the Corner Suites offer impressive river views but do not have balconies.
Are bathtubs available in the double rooms at 21C Museum Hotel?
15 August 2024
Yes, all Deluxe Double Rooms come with standard bathtubs, perfect for relaxation after a busy day.
Can guests request rollaway beds during their stay at the hotel?
5 September 2024
Rollaway beds are available upon request, and it's recommended to confirm availability by contacting the hotel directly.
Are there any refrigerator options available in the guest rooms?
12 October 2024
Guest rooms are equipped with stocked minibars, but for those needing a mini-fridge, a request can be made with the hotel prior to arrival.
What dining options are available on-site at the hotel?
30 November 2024
Proof on Main serves a unique menu inspired by Southern and Appalachian cuisine, making it a standout dining destination within the hotel.
Is there a spa or wellness facility at 21C Museum Hotel Louisville?
9 December 2024
The hotel features a spa with an on-site sauna and steam room, providing a perfect relaxation option for guests after exploring the city.
Can romantic packages or honeymoon suites be arranged for special occasions?
22 January 2025
Yes, any of the suites can be transformed into honeymoon suites with special packages that include dining credits and sweet amenities for couples.

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  • Location
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