Book Direct Here
and save up to 10%
Compared to Booking.com
Check rooms and rates
From209US$ /night
Check-in
25Jun2025Select date
Check-out
26Jun2025Select date
Rooms and Guests2 Guests, 1 Room
Key details

Hotel Overview

700 W Main Street, Louisville, Kentucky, United States, 40202

21C Museum Hotel Louisville is a 5-star boutique hotel that features contemporary art installations throughout its public spaces. It offers 91 uniquely designed guest rooms and a renowned on-site dining option called Proof on Main. Guests can enjoy over 9000 square feet of exhibition space showcasing curated contemporary art.

Rooms & Amenities

Rooms at 21C Museum Hotel feature modern design elements, including a premium Bryte Restorative Sleep Bed, allowing personalized adjustments to temperature and firmness. Each room includes a flat-screen TV, minibar, and free Wi-Fi. The largest room features an open floor plan with a king-sized bed along with living and dining areas.

Dining Options

Dining at the 21C Museum Hotel takes place at Proof on Main, known for its Appalachian-inspired cuisine and extensive bourbon selections. The culinary team can create tailored menus for events. A variety of dining options are within walking distance, including Atlantic No. 5 and Morton's The Steakhouse.

Meetings & Events

21C Museum Hotel serves as a unique venue for events with four private galleries accommodating groups of 10 to 60. The dedicated event staff helps manage details to create memorable celebrations and corporate gatherings. Guests can engage in local culture through nearby events like the Fork & Bottle dinner series featuring regional distillers.

Local Area & Transportation

Located within a half mile of attractions such as the Kentucky Museum of Art & Craft and the Muhammad Ali Center, the hotel connects guests to Louisville's vibrant culture. Public transport includes a nearby bus stop just a two-minute walk away. Guests can easily explore the downtown area and its historic sites.

View all

Pick the Room That Suits Your Travel Needs

Rooms for singles, families, or groups—many with breakfast, free cancellation, and exclusive airport packages
Room Balcony
Max:
2 persons
315 sq. feet 
Bed options:
1 King-size bed
City view
Shower
Coffee machine
Check Prices
Deluxe King Room
Max:
3 persons
335 sq. feet 
Bed options:
1 King-size bed
Shower
Coffee machine
Check Prices
Corner Suite
Max:
2 persons
660 sq. feet 
Bed options:
1 King-size bed
City view
Shower
Coffee machine
Check Prices
Show all roomsLess

View Room Rates & Availability by Date

Check rooms and compare prices for your travel dates today

How to Navigate the City

Explore Every Transit Option Around the Airport

City Centre
Louisville 1.2 mi
Airports
Louisville (SDF) 7.4 mi

Facilities

Comfortable Rooms and Convenient Services to Enhance Your Layover

General

  • No smoking on site
  • Wi-Fi
  • No parking
  • Safe deposit box
  • 24-hour reception
  • Pets allowed
  • Rooms/ Facilities for disabled
  • Wheelchair access
  • Security
  • Luggage storage
  • Locker room
  • Allergy-free rooms
  • Lift
  • ATM/Cash machine
  • Smoke detectors
  • Electric vehicle charging station
  • Fire extinguishers

Sports & Fitness

  • Fitness centre
  • Yoga class

Guest Parking

  • Cookware/ Kitchen utensils

Services

  • Valet parking
  • Room service
  • Housekeeping
  • Laundry
  • Dry cleaning
  • Welcome drink

Dining

  • Restaurant
  • Bar/ Lounge area
  • Outdoor dining area

Business

  • Business centre
  • Meeting/ Banquet facilities
  • Fax/Photocopying

Children

  • Cots

Spa & Leisure

  • Spa & wellness centre
  • Sauna
  • Turkish bath
  • Steam room
  • Full body massage

Room features

  • Air conditioning
  • Heating
  • Mini-bar
  • Soundproofed rooms
  • Patio
  • Tea and coffee facilities
  • Ironing facilities

Bathroom

  • Free toiletries

Self-catering

  • Cookware/ Kitchen utensils

Media

  • Flat-screen TV

Room decor

  • Carpeted floor
Show more

Location & Directions

700 W Main Street, Louisville, Kentucky, United States, 40202
Map view
700 W Main Street, Louisville, Kentucky, United States, 40202
Nearby
Museum
Louisville Slugger Museum & Bat Factory
600 ft
Museum
Muhammad Ali Center
1000 ft
Museum
Kentucky Science Center
500 ft
Museum
The Frazier History Museum
900 ft
Museum
Kentucky Museum of Art and Craft
300 ft
528 W Main St
Evan Williams Bourbon Experience
700 ft
Gallery
Flame Run Glass Studio and Gallery
1000 ft
500 W Main St
The Belvedere
900 ft
Night club
Jimmy Can't Dance
300 ft
801 W Main St
Michter's Fort Nelson Distillery
500 ft
Library
Sons of the American Revolution Genealogical Research Library
700 ft
120 N 10th St
Kentucky Peerless Distilling Co
1600 ft
401 W River Rd
Belle of Louisville Riverboats
2000 ft
Restaurants
Proof On Main
100 ft
702 West Main Street
Mussel & Burger Bar Downtown
200 ft
113 S 7th St Located in Louisville's Central Business District
Bristol Bar & Grille
400 ft
614 W Main St
Atlantic No. 5
600 ft
605 W Main St Located in Louisville's Central Business District.
Los Aztecas Mexican Restaurant
600 ft
445 E Market St
Vincenzo's Italian Restaurant
1500 ft
150 S 5th St
Jockey Silks Bourbon Bar
1600 ft
140 N 4th St 2nd Floor - West Tower
Dish on Market
1600 ft
434 W Market St
Quiznos
1800 ft
223 S 5th St
Swizzle Dinner & Drinks
1800 ft
140 N Fourth St 25th Floor
Cafe Magnolia
2000 ft
140 N 4th St Galt House Hotel
Interested in Early Bird Booking Discounts?
Unlock Special Airport Rates Instantly
Check Rates

Next best alternative

Consider them for your next trip.
Check-in
25Jun2025Select date
Check-out
26Jun2025Select date
Rooms and Guests2 Guests, 1 Room